Essential Role of Endogenous MOZ in Aberrant HoxA9 and Meis1 Expressions Induced By MOZ Fusion Gene

¡div class=”moz-text-flowed” style=”font-family: -moz-fixed”¿

For real numbers C, T 1 , T 2 , ... we find all solutions µ to the stochastic fixed point equation W j≥1 T j W j + C, where W, W 1 , W 2 , ... are independent real-valued random variables with distribution µ and means equality in distribution. All solutions are infinitely divisible. The set of solutions depends on the closed multiplicative subgroup of R * = R\{0} generated by the T j. If this g...

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.

The histone acetyltransferase MOZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p300, NCOA3, or TIF2 in particularly aggressive cases of acute myeloid leukemia. In this study, we report the role of wild-type MOZ in regulating B-cell progenitor proliferation and hematopoietic malignancy. In the Eμ-Myc model of aggressive pre-B/B-cell lymphoma, t...

MOZ-TIF2 Fusion Protein Binds to Histone Chaperon Proteins CAF-1A and ASF1B Through Its MOZ Portion

¡div class=”moz-text-flowed” style=”font-family: -moz-fixed”¿ ON TWO CONJECTURES CONCERNING CONVEX CURVES

In this paper we recall two basic conjectures on the developables of convex projective curves, prove one of them and disprove the other in the first nontrivial case of curves in RP . Namely, we show that i) the tangent developable of any convex curve in RP 3 has degree 4 and ii) construct an example of 4 tangent lines to a convex curve in RP 3 such that no real line intersects all four of them....

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome

DiGeorge syndrome, caused by a 22q11 microdeletion or mutation of the TBX1 gene, varies in severity greatly, even among monozygotic twins. Epigenetic phenomena have been invoked to explain phenotypic differences in individuals of identical genetic composition, although specific chromatin modifications relevant to DiGeorge syndrome are elusive. Here we show that lack of the histone acetyltransfe...